The Effect Of Lemon (Citrus limon) Juice on Serum BUN And Creatiinin Levels In Hyperuricemia Rattus norvegicus


Pengaruh Air Perasan Lemon (Citrus Limon) Terhadap Kadar Serum BUN dan Kreatinin pada Tikus Rattus Norvegicus yang Mengalami Hiperurisemia


  • (1) * Siti Nofiani Mufida            Universitas Muhammadiyah Sidoarjo  
            Indonesia

  • (2)  Puspitasari Puspitasari            Universitas Muhammadiyah Sidoarjo  
            Indonesia

    (*) Corresponding Author

Abstract

Hyperuricemia is a condition of increasing levels of uric acid in blood serum above normal values. Citrus limon contains flavonoids which have the ability to regenerate kidney function and play a role in reducing oxidative stress. The purpose of this study is to determine the effect of lemon juice (Citrus limon) on serum BUN levels and creatinine in Rattus norvegicus rats that experienced hyperuricemia. The research design used is quantitative analysis using experimental methods. This study used 24 Rattus norvegicus rats were divided into 6 groups. group 1 as normal control, group 2 as hyperuricemia control, group 3 with chicken liver juice and allopurinol 10 mg / g BB, group 4 with chicken liver juice and lemon juice 0,9 ml / 200g BB, group 5 with giving chicken liver juice and lemon juice a dose of 1.8 ml / 200 g BB, group 6 with the administration of chicken liver juice and lemon juice with a dose of 3.6 ml / 200 g BB orally. White mice are taken blood for BUN (Blood Urea Nitrogen) and creatinine. Based on the results of the One Way ANOVA statistical test, there was an effect of Citrus limon juice on BUN levels in group 5 with a value of 18,425 mg/dl, while at creatinine levels which affected Citrus limon juice in group 5 of 0,250 mg/dl.

References

Ariyanti, R., Wahyuningtyas, N., & Wahyuni, S. A. (2007). Pengaruh Pemberian Infusa Daun Salam (Eugenia polyantha Wight) Terhadap Penurunan Kadar Asam Urat Darah Mencit Putih Jantan Yang Diinduksi Dengan Potasium Oksonat. PHARMACON, 8(2), 56-63. Retrieved from https://publikasiilmiah.ums.ac.id/handle/11617/948

Dalimartha, S., & Adrian, F. (2013). Fakta Ilmiah Buah & Sayur. Jakarta: Penebar Plus.

Hardman, J. G., & Limbird, L. E. (2008). Goodman dan Gilman Dasar Farmakologi Terapi. Edisi II. Bandung: ITB. hh: 47-70.

Hasanah, N. L. N., Indriyanti, A. R., & Andriane, Y. (2015). Perbandingan Pemberian Allopurinol dan Air Jeruk Nipis (Citrus Aurantifolia) Terhadap Kadar Asam Urat Pada Mencit Hiperurisemia. Prosiding Pendidikan Dokter. Seminar Penelitian Sivitas Akademika Unisba (SPeSIA). Universitas Islam Bandung, 49-51. Retrieved from http://karyailmiah.unisba.ac.id/index.php/dokter/article/view/1073/pdf

Hayani, M., & Widyaningsih, W. (2011). Efek Ekstrak Etanol Herba Putri Malu (Mimosa Purica, L) Sebagai Penurunan Kadar Asam Urat Serum Mencit Jantan Galur Swiss. Prosiding Seminar Nasional "Home Care". Universitas Ahmad Dahlan, Juni 2011, 29-33. Retrieved from http://eprints.uad.ac.id/1428/1/05_Ibu_Wahyu-Efek_Ekstrak.pdf

Murnah, & Indranila, K. S. (2014). Pengaruh Ekstrak Etanol Mengkudu (Morinda citrifolia L) Terhadap Diabetik Nefropati Pada Tikus Sprague Dawley Yang Diinduksi Streptozocotin (STZ). JNH, 2(1), 1-15. Retrieved from https://media.neliti.com/media/publications/89895-ID-none.pdf

Kemenkes RI. (2017). Situasi Penyakit Ginjal Kronik. Pusat data dan Informasi. Jakarta: Kementrian Kesehatan Republik Indonesia.

Lau, E. (2009). Healthy Express: Super Sehat Dalam 2 Minggu. Jakarta: Gramedia Pustaka Utama.

Nuari, A. N., & Widayati, D. (2017). Gangguan Pada Sistem Perkemihan &

Penatarlaksanaan Keperawatan. Yogyakarta: Deepublish.

Sari, A., & Mangunsong, S. (2014). Efek Ekstrak Daun Sirih (Piper betle L.) Terhadap Penurunan Kadar Serum Asam Urat Dan Ureum Pada Tikus Putih. Mutiara Medika, 14(1), 93-99. Retrieved from https://journal.umy.ac.id/index.php/mm/article/view/2475/2455

Susanto, B. D. (2014). Jus Dahsyat Tumpas Penyakit Sehat & Awet Muda. Yogyakarta: Cemerlang Publishing.

Verdiansah. (2016). Pemeriksaan Fungsi Ginjal. Cermin Dunia Kedokteran (CDK)-237, 43(2), 148-154. Retrieved from http://www.cdkjournal.com/index.php/CDK/article/view/25/23

Published
2020-07-27
 
Section
Articles